- 2009: Earned an Emmy nomination for her guest-starring role as Dr. Beverly Hofstadter, an unemotional expert in psychiatry and neural science, and Leonard’s (Johnny Galecki) mom in a episode of "The Big Bang Theory" (CBS)
- 2009: Cast opposite Julianna Margulies in the CBS drama, "The Good Wife"
- 2008: Starred in the Broadway revival of "Boeing-Boeing"
- 2008: Cast in the film adaptation of the ABBA stage musical "Mamma Mia!"
- 2006: Played the title role in the Broadway revival of "Mame" at the Kennedy Center
- 2004: Appeared in the comedy "Welcome to Mooseport"
- 2003: Appeared in the Hollywood/Bollywood satire "The Guru"
- 2003: Co-starred with John Larroquette in the NBC sitcom "Happy Family"
- 2002: Played reporter Mary Sunshine in the film version of "Chicago"
- 2002: Cast as Mrs. Lovett in the Kennedy Center production of "Sweeney Todd"
- 2000: Executive produced and starred in the short-lived CBS sitcom "Welcome to New York"
- 2000: Had featured role as the title character's childhood sweetheart in "How the Grinch Stole Christmas"
- 1999: Garnered an Emmy nomination for her memorable guest appearance on NBC's "Frasier" as radio host Dr. Nora
- 1999: Played fading diva opposite Steve Martin and Eddie Murphy in the comedy "Bowfinger"
- 1999: Returned to the stage as Mrs. Lovett in L.A.'s Reprise! concert production of "Sweeney Todd" co-starring Grammer
- 1998: Had featured role as a rauchy biker chick in "The Odd Couple II"
- 1998: Played the wife of Warren Beatty's suicidal US Senator in the political comedy "Bulworth"
- 1997: Starred in the Encores! presentation of "Promises, Promises" opposite Martin Short at Manhattan's City Center
- 1996: Appeared as Robin Williams' ex-wife in the Mike Nichols-directed "The Birdcage"
- 1995: Cast as Cybill Shepherd's hard-drinking friend Maryanne Thorpe in the CBS sitcom "Cybill"
- 1994: Delivered another gemlike comic performance as Kevin Spacey's hoity-toity sister-in-law in "The Ref"
- 1993: Offered a strong comic turn as a camp counselor in "Addams Family Values"
- 1991: Appeared in "Lips Together, Teeth Apart" at the Manhattan Theatre Club
- 1991: Starred in the ill-fated musical "Nick and Nora"
- 1990: Portrayed Andrea Reynolds opposite Irons' Claus von Bulow and Close's Sunny von Bulow in "Reversal of Fortune"
- 1988: Co-starred on Broadway in the Neil Simon comedy "Rumors"; picked up second Tony Award
- 1986: Replacing Stockard Channing as Bunny Flingus in the acclaimed Broadway revival of John Guare's comedy-drama, "The House of Blue Leaves" (reprised role in the TV version)
- 1985: Replaced Judith Ivey on the Broadway stage in the acclaimed production of David Rabe's play, "Hurlyburly"
- 1984: First garnered attention as a meter maid in Louis Malle's comedy "Crackers"
- 1984: Co-starred Glenn Close in Tom Stoppard's Broadway comedy "The Real Thing"; directed by Mike Nichols
- 1982: Feature film debut, "Soup for One"
- 1980: Made Broadway debut in "Hide and Seek"
- 1980: Had supporting role in the landmark CBS TV drama "Playing for Time"
- 1976: Appeared in a Baltimore production of "She Stoops to Conquer"
- 1976: Was member of the company of the McCarter Theatre in Princeton, New Jersey
- Born in Buffalo, New York
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