Family
- father John Aniston: Born c. 1933; appeared in NBC daytime serial "Days of Our Lives"; divorced Aniston's mother in 1980, leaving her for another woman; family name was originally Anastassakis
- mother Nancy Aniston: Born c. 1936; previously married before her 1965 marriage to John Aniston; divorced from Aniston in 1980; because of comments made in a TV interview c. 1995, daughter has ceased contact; wrote book From Mother and Daughter to Friends (1999)
- godfather Telly Savalas: Her father, John Aniston was good friends with the fellow Greek actor at the time of her birth; best known for his series “Kojak” (CBS, 1973-79); died in 1994
- half-brother John Melick: Born c. 1959; mother, Nancy Aniston
Companions
- husband Brad Pitt: Met in 1998; married July 29, 2000 in Malibu, CA; announced separation Jan. 6, 2005, after more than fours years of marriage; Aniston filed for divorce in March 2005; their divorce was finalized in October 2005
- Companion Vince Vaughn: Rumors of the pair dating began while filming "The Break Up" (2006); they were first spotted kissing at a wrap party in August 2005; relationship troubles reported in September 2006 with an "official" split by December 2006
- Companion John Mayer: Began dating in April 2008; briefly split in August 2008, but resumed relationship in October 2008; accompanied Aniston to the 2009 Oscar ceremony in February; rumored to have once again split in March 2009
- Adam Duritz: with band Counting Crows; dated briefly in 1995
- husband Brad Pitt: married on July 29, 2000 in Malibu, California
- Charlie Schlatter: dated when they co-starred on "Ferris Bueller" in 1990
- Daniel MacDonald: dated in the 1990s; broke up just before Aniston was cast in "Friends"
- Tate Donovan: together since November 1995; born on September 25, 1963; separated c. April 1998
- Companion Paul Sculfor: Rumored to have dated for a few months in 2007
