- 2008: Lent her voice to the live-action comedy "Beverly Hills Chihuahua"
- 2008: Featured opposite Kevin Costner in the comedy "Swing Vote"
- 2007: Performed the HBO stand-up special "America's Mexican"
- 2007: Played FBI Agent Ernie Rodriguez in the comedy "Balls of Fury"
- 2005: Co-starred with Dennis Quaid and Rene Russo in the remake of "Yours, Mine and Ours"
- 2005: Cast in Robert Rodriguez's "The Adventures of Shark Boy & Lava Girl in 3-D"
- 2004: Performed in his first TV comedy special, "Why You Crying?" (premiered on Showtime)
- 2003: Earned Grammy nomination for Best Comedy Album for Team Leader
- 2002: Co-created (also wrote and co-produced) and played the lead role in the ABC sitcom "George Lopez"; also produced by Sandra Bullock who pushed to get a sitcom on television after watching his stand-up
- 2002: Co-starred in the independent comedy feature "Real Women Have Curves"
- 2000: Cast in the comedy feature "Bread and Roses"
- 1993: Portrayed an investigator in the comedy spoof "Fatal Instinct"
- 1990: Cast in the comedy feature "Ski Patrol"
- 1980: Feature debut in Bruce Lee's "Fist of Fear, Touch of Death"
- Worked the comedy-club circuit for two decades
- Performed standup for the first time at the age of 18




