Derailed (2006)

Based on the James Siegel novel, Charles Schine is a New York businessman who meets a sexy woman on a train and ends up in a seedy hotel room with her. While there, he's beaten and she is raped by a man who also robs them. The robber then begins to blackmail Schine so that his wife and family don't find out about his infidelity with the woman. This drives Schine from his humdrum life into a world of fraud, betrayal and murder.

Official website: http://www.weinsteinco.com/derailed/